Our group is pursuing a variety of research projects in the field of metalloproteins and assay development.
We are currently involved in studies on zinc enzymes, including anthrax lethal factor, thermolysin, carboxypeptidase A, and metallo-β-lactamases. We are also interested in the folding and unfolding of metalloproteins. Finally, we have been active in the development of metal quantification methods and enzyme assays. Regarding the latter aspect, we have recently started working on the development of new assays for the COVID-19 main protease.
We are always looking for new M.Sc. and Ph.D. students to tackle our projects. Our research is well-funded by various Canadian granting agencies.
New students are exposed, in a hands-on fashion, to state-of-the-art instrumentation (stopped-flow spectrophoto/fluorometers, platereaders, ICP-MS, ESI-MS, fermenters).
Dr. Stefan Siemann studied chemistry at the University of Paderborn (Germany) before going to the University of Waterloo (Canada) as part of a scholarship-sponsored foreign exchange program.
He finished his M.Sc./Diploma at the Universities of Waterloo and Paderborn before initiating his Ph.D. studies at the University of Bielefeld, Germany. Following his Ph.D. in chemistry in 2000, he went back to UWaterloo as a post-doctoral fellow working on antibiotic resistance.
Since 2004, Dr. Siemann is a faculty member of the Dept. of Chemistry and Biochemistry at Laurentian University.